All southbound lanes on Interstate-81 were closed early Sunday evening in Frederick County, Va., after a multi-vehicle accident involving a wrong-way driver.
Emergency dispatchers said it happened north of Winchester near mile marker 321, just after 6 p.m.
Three people were hurt in the crash, and they were all taken to Winchester Medical Center for treatment of minor injuries.
Traffic was backed up for miles, as motorists were advised to expect major delays.
Virginia State Police is handling the investigation.